The verse highlights a fundamental issue in human behavior: the absence of reverence for God. This lack of fear does not imply terror but rather a deficiency in respect and acknowledgment of God's sovereignty and moral authority. When individuals do not have a healthy fear of God, they may live without regard for His commands or the consequences of their actions. This can lead to moral decay and a society where ethical standards are ignored.
In a broader context, this verse is part of a passage where Paul is addressing the universal nature of sin and the need for divine grace. He points out that all have sinned and fall short of God's glory, emphasizing that without a proper understanding and respect for God, people are prone to follow their own desires rather than divine guidance. Recognizing God's authority can lead to a more disciplined and morally aligned life, encouraging believers to live in a way that honors God and reflects His love and righteousness.