Human nature, when driven by selfish desires and worldly concerns, tends to resist God's guidance and principles. Such a mindset is often at odds with the spiritual path that God desires for us. This verse highlights the inherent conflict between a life led by fleshly desires and one that seeks to follow God's law. The mind governed by the flesh is not just indifferent but actively hostile to God's ways, unable to submit to His law due to its focus on self-interest and immediate gratification.
The call here is for a transformation of the mind, urging believers to shift their focus from temporary, earthly desires to eternal, spiritual truths. By doing so, they can move from a state of conflict and resistance to one of harmony and peace with God's will. This transformation is essential for living a life that reflects God's love and purpose, allowing believers to experience the fullness of life that comes from being in alignment with His divine plan.