The verse contrasts two ways of living: one according to the flesh and the other by the Spirit. Living according to the flesh means following our sinful nature and desires, which ultimately leads to spiritual death. This death is not just physical but a separation from the life and presence of God. On the other hand, living by the Spirit involves allowing the Holy Spirit to guide and empower us to overcome sinful behaviors. This process is often referred to as sanctification, where the Spirit helps us to 'put to death' the misdeeds of the body.
This transformation leads to true life, which is not just about eternal life after death but also a quality of life here and now, filled with peace, purpose, and a deep connection with God. The verse encourages believers to actively participate in this transformation by choosing to follow the Spirit's leading, which results in a life that reflects God's love and righteousness. It highlights the importance of spiritual discipline and reliance on God's power to live a life that honors Him.